Severe acidosis due to 5-oxoprolinase inhibition by flucloxacillin in a patient with shoulder prosthesis joint infection

Julia Elisabeth Lenz; Volker Alt; Thomas Dienemann

doi:10.5194/jbji-7-71-2022

Severe acidosis due to 5-oxoprolinase inhibition by flucloxacillin in a patient with shoulder prosthesis joint infection

J Bone Jt Infect. 2022 Apr 4;7(2):71-74. doi: 10.5194/jbji-7-71-2022. eCollection 2022.

Authors

Julia Elisabeth Lenz¹, Volker Alt¹, Thomas Dienemann²

Affiliations

¹ Department of Trauma Surgery, University Medical Center Regensburg, Regensburg, Germany.
² Department of Surgery, Surgical Intensive Care Unit, University Medical Center Regensburg, Regensburg, Germany.

Abstract

We report a case of a 64-year-old female patient with severe metabolic acidosis. Inhibition of 5-oxoprolinase by flucloxacillin was found to be the cause of the metabolic derailment.

Publication types

Case Reports