Extracellular Vesicles, New Players in Sepsis and Acute Respiratory Distress Syndrome

Wenqiang Jing; Huijuan Wang; Liying Zhan; Wei Yan

doi:10.3389/fcimb.2022.853840

Extracellular Vesicles, New Players in Sepsis and Acute Respiratory Distress Syndrome

Front Cell Infect Microbiol. 2022 Apr 7:12:853840. doi: 10.3389/fcimb.2022.853840. eCollection 2022.

Authors

Wenqiang Jing¹, Huijuan Wang², Liying Zhan², Wei Yan¹

Affiliations

¹ Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.
² Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China.

Abstract

Sepsis refers to a complex syndrome associated with physiological, pathological, and biochemical abnormalities resulted from infection. Sepsis is the major cause of acute respiratory distress syndrome (ARDS). Extracellular vesicles (EVs) are serving as new messengers to mediate cell-cell communication in vivo. Non-coding RNAs, proteins and metabolites encapsulated by EVs could result in either pro-inflammatory or anti-inflammatory effects in the recipient cells. Pathogens or host cells derived EVs play an important role in pathogens infection during the occurrence and development of sepsis and ARDS. Additionally, we summarize the potential application for EVs in diagnosis, prevention and treatment for sepsis and ARDS.

Keywords: ARDS; diagnosis; engineering; extracellular vesicles; sepsis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell Communication
Extracellular Vesicles* / metabolism
Humans
Respiratory Distress Syndrome*
Sepsis* / metabolism