Effectiveness of intra-venous steroids for preventing surgery for lumbo-sacral radiculopathy secondary to intervertebral disc herniation: a retrospective study of 213 patients

Sci Rep. 2022 Apr 23;12(1):6681. doi: 10.1038/s41598-022-10659-1.

Abstract

The natural history of lumbar disc herniation with radiculopathy is favorable, with 95% of patients expected to be pain-free within 6 months of onset. Despite the favorable prognosis, operative treatment is often chosen by patients unable to "ride out" the radicular episode. Prospective studies comparing surgical with non-surgical treatment have demonstrated similar long-term results. We conducted a retrospective case-series study of patients with a lumbar disc herniation and intractable radicular pain without significant neurological deficits treated with intra-venous dexamethasone. The primary outcome measure was whether the patient had undergone operative treatment within 1 year of receiving the intravenous steroid treatment. 213 patients met our inclusion criteria. 30 were lost to follow-up and 2 had died before completing 1 year of follow-up. Of the remaining 181 patients, 133 (73.48%) had not undergone surgery within 1 year of receiving intra-venous steroid treatment while 48 (26.51%) had undergone surgery. 6 (3.31%) of the patients had undergone surgery more than 1 year of receiving IV steroid treatment. Intravenous steroid treatment in our retrospective series was approximately 30% better at preventing the need for surgery than the reported outcomes of conservative treatment in randomized controlled trials previously published.

MeSH terms

  • Humans
  • Intervertebral Disc Displacement* / complications
  • Intervertebral Disc Displacement* / drug therapy
  • Intervertebral Disc Displacement* / surgery
  • Lumbar Vertebrae / surgery
  • Prospective Studies
  • Radiculopathy* / complications
  • Radiculopathy* / etiology
  • Retrospective Studies
  • Steroids / therapeutic use
  • Treatment Outcome

Substances

  • Steroids