Two new chromanone acids from the stem bark of Calophyllum peekelii Lauterb

Tjitjik Srie Tjahjandarie; Wisnu Aji Setyo Nugroho; Hady Palgunadi; Ratih Dewi Saputri; Mulyadi Tanjung

doi:10.1080/14786419.2022.2062754

Two new chromanone acids from the stem bark of Calophyllum peekelii Lauterb

Nat Prod Res. 2023 Oct-Nov;37(19):3214-3219. doi: 10.1080/14786419.2022.2062754. Epub 2022 Apr 22.

Authors

Tjitjik Srie Tjahjandarie¹, Wisnu Aji Setyo Nugroho¹, Hady Palgunadi¹, Ratih Dewi Saputri², Mulyadi Tanjung¹

Affiliations

¹ Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
² Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya, Indonesia.

PMID: 35459432
DOI: 10.1080/14786419.2022.2062754

Abstract

Three chromanone acids were isolated from the stem bark of Calophyllum peekelii Lauterb. Among them are two new chromanone acids, calopeekelioic acids A (1) and B (2), along with calolongic acid (3), Their structures were established by analyzing a combination of HRESIMS, 1 D, and 2 D NMR spectra. Chromanone acids 1-3 were evaluated for their antiplasmodial activity against Plasmodium falciparum strain 3D7. Compounds 1-2 showed high activity with an IC₅₀ value of 1.70 and 1.01 µg/mL, respectively.

Keywords: Calopeekelioic acids A-B; Calophyllum peekelii; antiplasmodial; chromanone acid.