Experimental Testing of an Approach to Establishing Combined Toxicity of Ternary Nanoparticle Mixtures

Ilzira A Minigalieva; Vladimir G Panov; Vladimir B Gurvich; Larisa I Privalova; Svetlana V Klinova; Boris A Katsnelson

doi:10.3390/ijms23084356

Experimental Testing of an Approach to Establishing Combined Toxicity of Ternary Nanoparticle Mixtures

Int J Mol Sci. 2022 Apr 14;23(8):4356. doi: 10.3390/ijms23084356.

Authors

Ilzira A Minigalieva¹, Vladimir G Panov^{1

2}, Vladimir B Gurvich¹, Larisa I Privalova¹, Svetlana V Klinova¹, Boris A Katsnelson¹

Affiliations

¹ Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Yekaterinburg, Russia.
² Institute of Industrial Ecology, Ural Branch of the Russian Academy of Sciences, 620049 Yekaterinburg, Russia.

Abstract

Our studies of exposure to binary mixtures of nanoparticles (TiO₂ + SiO₂; TiO₂ + Al₂O₃ and SiO₂ + Al₂O₃) based on mathematical modelling show that their combined subchronic toxicity can either be of an additive type or deviate from it depending on the outcome, dose ratio, and levels of effect. To characterize the type of toxicity of ternary mixtures of nanoparticles, we successfully tested a previously developed approach for assessing the combined toxicity of metal ions. In this approach, the effects are classified by a null, positive, or negative change in the toxicity of binary nanoparticle mixtures when modeled against the toxicity of the third agent added.

Keywords: combined toxicity; mathematical modelling; ternary nanoparticle mixtures.

MeSH terms

Ions
Models, Theoretical
Nanoparticles* / toxicity
Silicon Dioxide* / toxicity

Substances

Ions
Silicon Dioxide