New sheriff in town: Cyclic peptide inhibitors of a DUB module

Shamshad Alam; Boyko S Atanassov

doi:10.1016/j.chembiol.2022.04.001

New sheriff in town: Cyclic peptide inhibitors of a DUB module

Cell Chem Biol. 2022 Apr 21;29(4):541-543. doi: 10.1016/j.chembiol.2022.04.001.

Authors

Shamshad Alam¹, Boyko S Atanassov²

Affiliations

¹ Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
² Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. Electronic address: boyko.atanassov@roswellpark.org.

PMID: 35452621
DOI: 10.1016/j.chembiol.2022.04.001

Abstract

In this issue of Cell Chemical Biology, Morgan et al. (2021) show that cyclic peptides can be potent and highly specific inhibitors for deubiquitinating enzymes. This study identifies the first selective inhibitors of the cancer-associated ubiquitin-specific protease 22 (USP22).

MeSH terms

Peptides, Cyclic* / pharmacology

Substances

Peptides, Cyclic