A Valence-Engineered Self-Cascading Antioxidant Nanozyme for the Therapy of Inflammatory Bowel Disease

Quan Wang; Chaoqun Cheng; Sheng Zhao; Quanyi Liu; Yihong Zhang; Wanling Liu; Xiaozhi Zhao; He Zhang; Jun Pu; Shuo Zhang; Huigang Zhang; Yan Du; Hui Wei

doi:10.1002/anie.202201101

A Valence-Engineered Self-Cascading Antioxidant Nanozyme for the Therapy of Inflammatory Bowel Disease

Angew Chem Int Ed Engl. 2022 Jul 4;61(27):e202201101. doi: 10.1002/anie.202201101. Epub 2022 May 5.

Authors

Quan Wang¹, Chaoqun Cheng¹, Sheng Zhao¹, Quanyi Liu^{2

3}, Yihong Zhang¹, Wanling Liu¹, Xiaozhi Zhao⁴, He Zhang⁵, Jun Pu⁶, Shuo Zhang^{1

7}, Huigang Zhang^{1

7}, Yan Du^{2

3}, Hui Wei^{1

8}

Affiliations

¹ College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu, 210023, China.
² State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
³ University of Science and Technology of China, Hefei, Anhui, 230026, China.
⁴ Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing, Jiangsu, 210008, China.
⁵ Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210093, China.
⁶ Key Laboratory of Functional Molecular Solids, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241002, China.
⁷ Collaborative Innovation Center of Advanced Microstructures and Institute of Materials Engineering, Nanjing University, Nanjing, Jiangsu, 210093, China.
⁸ State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, Jiangsu, 210023, China.

PMID: 35452169
DOI: 10.1002/anie.202201101

Abstract

Antioxidant treatment strategy by scavenging reactive oxygen species (ROS) is a highly effective disease treatment option. Nanozymes with multiple antioxidant activities can cope with the diverse ROS environment. However, lack of design strategies and limitation of negative correlation for nanozymes with multiple antioxidant activities hindered their development. To overcome these difficulties, here we used ZnMn₂ O₄ as a model to explore the role of Mn valency at the octahedral site via a valence-engineered strategy, and found that its multiple antioxidant activities are positively correlated with the content of Mn⁴⁺ . Therefore, through this strategy, a self-cascading antioxidant nanozyme LiMn₂ O₄ was constructed, and its efficacy was verified at the cellular level and in an inflammatory bowel disease model. This work not only provides guidance for the design of multiple antioxidant nanozymes, but also broadens the biomedical application potential of multiple antioxidant nanozymes.

Keywords: Antioxidant; Reactive Oxygen Species; Self-Cascade Nanozyme; Spinel Oxide; Valence-Engineering Strategy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antioxidants* / pharmacology
Humans
Inflammatory Bowel Diseases* / drug therapy
Reactive Oxygen Species

Substances

Antioxidants
Reactive Oxygen Species