Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population

Oksana S Pogorielova; Viktoriia V Korniienko; Yaroslav D Chumachenko; Olha A Obukhova; Igor Martsovenko; Viktoriia Yu Harbuzova

doi:10.1155/2022/2067632

Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population

Cardiol Res Pract. 2022 Apr 11:2022:2067632. doi: 10.1155/2022/2067632. eCollection 2022.

Authors

Oksana S Pogorielova¹, Viktoriia V Korniienko², Yaroslav D Chumachenko³, Olha A Obukhova⁴, Igor Martsovenko⁵, Viktoriia Yu Harbuzova³

Affiliations

¹ Department of Internal Medicine with Center of Respiratory Medicine, Sumy State University, Sumy 40007, Ukraine.
² Biomedical Research Center, Sumy State University, Sumy 40018, Ukraine.
³ Scientific Laboratory of Molecular Genetic Studies, Sumy State University, Sumy 40007, Ukraine.
⁴ Department of Physiology and Pathophysiology with Medical Biology Course, Sumy State University, Sumy 40018, Ukraine.
⁵ Municipal Non-Profit Enterprise of Sumy Regional Council "Sumy Regional Cardiological Clinic", Sumy 40030, Ukraine.

Abstract

Coronary artery disease (CAD) is one of the leading causes of death in Europe. It is known that atherosclerosis is the primary risk factor of CAD development. MMP-9 is involved in all stages of atherosclerosis and thus may contribute to CAD emergence. To investigate the influence of MMP-9 on the (CAD) development 25 patients with intact coronary arteries (CA), 40 patients with acute coronary syndrome (ACS), and 63 patients with chronic coronary syndrome (CCS) were enrolled in the study. Real-time PCR was carried out for genotyping on the rs17567-polymorphic locus, and ELISA study was performed to measure the MMP-9 plasma concentration. It was found the lower risk of MI occurrence for AG-carriers (P _a =0.023; OR_a = 0.299, 95% CI = 0.106-0.848) in Ukrainian population.