Characterization of Chelation and Absorption of Calcium by a Mytilus edulis Derived Osteogenic Peptide

Zhe Xu; Shiying Han; Hui Chen; Zhixuan Zhu; Lingyu Han; Xiufang Dong; Ming Du; Tingting Li

doi:10.3389/fnut.2022.840638

Characterization of Chelation and Absorption of Calcium by a Mytilus edulis Derived Osteogenic Peptide

Front Nutr. 2022 Apr 5:9:840638. doi: 10.3389/fnut.2022.840638. eCollection 2022.

Authors

Zhe Xu¹, Shiying Han¹, Hui Chen², Zhixuan Zhu¹, Lingyu Han¹, Xiufang Dong³, Ming Du⁴, Tingting Li¹

Affiliations

¹ Key Laboratory of Biotechnology and Bioresources Utilization, College of Life Sciences, Dalian Minzu University, Ministry of Education, Dalian, China.
² Key Laboratory of Marine Fishery Resources Exploitment and Utilization of Zhejiang Province, College of Food Science and Technology, Zhejiang University of Technology, Hangzhou, China.
³ College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Qingdao, China.
⁴ National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, School of Food Science and Technology, Dalian Polytechnic University, Dalian, China.

Abstract

In a previous study, the peptide LGKDQVRT, which was identified by enzymatic hydrolysis, released during the proteolysis of Mytilus edulis, had potential osteogenic activity. In this study, the octapeptide LGKDQVRT was able to spontaneously bind calcium in a 1:1 stoichiometric ratio, and the calcium-binding site likely involves calcium and amino acid VAL6 in the LGKDQVRT peptide to form a metal-donor to metal acceptor complex. The peptide LGKDQVRT has the activity of promoting the proliferation and differentiation of osteoblasts. The results of this study suggest that hydrolyzed peptides from Mytilus edulis protein can be used as a dietary supplement to improve calcium absorption and prevent osteoporosis.

Keywords: Mytilus edulis; absorption; bone; calcium; peptide.