Group dynamics goes awry: PolyQ-expanded huntingtin gains unwanted partners

Leonardo E Dionisio; X William Yang

doi:10.1016/j.cels.2022.03.003

Group dynamics goes awry: PolyQ-expanded huntingtin gains unwanted partners

Cell Syst. 2022 Apr 20;13(4):268-270. doi: 10.1016/j.cels.2022.03.003.

Authors

Leonardo E Dionisio¹, X William Yang²

Affiliations

¹ Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human behavior, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; UCLA Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA.
² Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human behavior, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; UCLA Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: xwyang@mednet.ucla.edu.

PMID: 35447076
DOI: 10.1016/j.cels.2022.03.003

Abstract

In this issue of Cell Systems, Greco et al. define high-confidence polyglutamine-dependent huntingtin interactors using AP-MS and complementary approaches and categorize them based on their interaction abundance and stability. The study reveals that a toxic gain of polyQ-dependent Htt interacting partners is a robust feature of HD pathogenesis.

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MeSH terms

Huntingtin Protein / genetics
Nuclear Proteins* / genetics
Peptides* / genetics

Substances

Huntingtin Protein
Nuclear Proteins
Peptides
polyglutamine