Paraganglioma in pregnancy: A case series and literature review

Jade Eccles-Smith; Stephanie Hopkins; Jennifer Conn; Stephanie Johnston; Rebecca Szabo; Sarah Price; Alison Nankervis

doi:10.1177/1753495X211006012

Paraganglioma in pregnancy: A case series and literature review

Obstet Med. 2022 Mar;15(1):19-24. doi: 10.1177/1753495X211006012. Epub 2021 Apr 20.

Authors

Jade Eccles-Smith¹, Stephanie Hopkins², Jennifer Conn^{1

3

4}, Stephanie Johnston^{5

6}, Rebecca Szabo^{1

7

8}, Sarah Price^{1

3

4}, Alison Nankervis^{1

3

4}

Affiliations

¹ Department of Obstetrics and Gynaecology, Royal Women's Hospital, Parkville Victoria, Australia.
² Department of Medicine, University of Newcastle, Callaghan New South Wales, Australia.
³ Department of Diabetes and Endocrinology, Royal Melbourne Hospital, Australia.
⁴ Department of Medicine, University of Melbourne, Parkville Victoria, Australia.
⁵ University Hospital, Geelong Victoria, Australia.
⁶ School of Medicine, Deakin University, Geelong Victoria, Australia.
⁷ Department of Medical Education, University of Melbourne, Parkville Victoria, Australia.
⁸ Gandel Simulation Service, Royal Women's Hospital, University of Melbourne, Parkville Victoria, Australia.

Abstract

Paragangliomas are rare neuroendocrine neoplasms which are often catecholamine-secreting and associated with familial syndromes. Described here are three women with a variety of pathology: isolated secretory paraganglioma diagnosed in pregnancy, secretory metastatic paraganglioma in pregnancy and non-secretory metastatic paraganglioma in pregnancy. Whilst paragangliomas are associated with morbidity and mortality during pregnancy, good maternal and fetal outcomes can be achieved through individualised care within the context of a multidisciplinary team. Although paragangliomas are associated with morbidity and mortality in pregnancy, good maternal and fetal outcomes can be achieved through individualised care within the context of a multidisciplinary team.

Keywords: Paraganglioma; catecholamines; hypertension; pregnancy outcomes.

Publication types

Review