Impact of Myocardial Energy Expenditure and Diastolic Dysfunction on One Year Outcome Patients With HFpEF

Yu Wang; Yalan Cao; Shuting Xiang; Shunji Liang; Xiumei Yang; Ning Zhu; Weiyi Fang; Qin Yu

doi:10.3389/fphys.2022.655827

Impact of Myocardial Energy Expenditure and Diastolic Dysfunction on One Year Outcome Patients With HFpEF

Front Physiol. 2022 Apr 4:13:655827. doi: 10.3389/fphys.2022.655827. eCollection 2022.

Authors

Yu Wang^{1

2

3}, Yalan Cao^{1

4}, Shuting Xiang^{1

4}, Shunji Liang⁵, Xiumei Yang¹, Ning Zhu⁶, Weiyi Fang⁷, Qin Yu¹

Affiliations

¹ Department of Cardiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
² Department of Nephrology, Affiliated Xinhua Hospital of Dalian University, Dalian, China.
³ Dalian Medical University, Dalian, China.
⁴ Zunyi Medical University, Zunyi, China.
⁵ Department of Echocardiogram, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
⁶ Department of Cardiology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
⁷ Department of Cardiology, Shanghai Chest Hospital, Shanghai, China.

Abstract

Objective: To explore the correlation between characteristics of myocardial energy expenditure (MEE) and the degree of diastolic dysfunction in patients of heart failure with preserved ejection fraction (HFpEF) and its clinical significance. Methods: 125 consecutive patients diagnosed with HFpEF in the Department of Cardiology, Affiliated Zhongshan Hospital of Dalian University from January 2018 to October 2018 were enrolled. According to the degree of diastolic dysfunction, patients were divided into group A (8 ≤ E/e' ≤15) and group B (E/e'> 15), and MEE was calculated, patients finished 1-year clinical follow-up. Results: The level of MEE in group A was significantly lower than that in group B (p < 0.05). During 1-year follow up, MEE over 3145.69 kcal/systole was associated with increased risk of death as compared to patients with MEE less 3145.69 kcal/systole, and in patients with MEE over 101.68 kcal/min than in patients with MEE less than 101.68 kcal/min. Conclusion: There is a significant correlation between MEE and diastolic dysfunction and MEE over 3145.69 kcal/systole as well as MEE over 101.68 kcal/min are linked with increased risk of 1-year mortality in HFpEF.

Keywords: HFpEF; MEE; cardiology; diastolic dysfunction; energy metabolism.