Diabetes mellitus, a prothrombotic state with enhanced platelet reactivity, presents with altered platelets indices. Increased platelet activation has been suggested to be involved in the pathogenesis of vascular complications of T2DM.
Material: This was a prospective observational study carried from December 2019 to June 2021, to evaluate the alteration in Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Plateletcrit (PCT) and Platelet Large Cells Ratio (P-LCR) among 150 patients with T2DM who were admitted in In Patient Department in Department of General Medicine in a tertiary care centre after taking their verbal consent.
Observation: The results showed a significant increase in mean MPV (10.27±1.18 vs. 8.58±0.74fl, p<0.001), PDW (12.86±0.89 vs. 11.03±1.61fl, p<0.001), PCT (0.247±0.006 vs. 0.233±0.008%, p<0.001) and P-LCR (41.10±5.62 vs. 37.73±4.26% p<0.001) among those with poor glycemic control than those with good glycemic control. But only higher mean MPV (10.24±1.24 vs. 8.83±0.94fl, p=0.001) were present among those with proteinuria than among those without proteinuria and higher mean MPV (10.22±1.17 vs. 8.81±1.05fl, p<0.001), PDW (12.39±1.22 vs. 11.79±1.78fl, p-0.015) and P-CLR (40.66±6.01 vs. 38.63±4.18% p=0.022) were present among those retinopathy than among those without retinopathy.
Conclusion: MPV can be used as a simple and cost-effective laboratory tool to monitor the progression and control of DM and especially its microvascular complications thereby help reduce the morbidity and mortality.
© Journal of the Association of Physicians of India 2011.