A simple iodine-DMSO-promoted multicomponent reaction for the synthesis of 2,4-disubstituted dihydrotriazole-3-ones

Hui Liao; Zesheng Huang; Qiuhua Zhu

doi:10.1039/d2ob00352j

A simple iodine-DMSO-promoted multicomponent reaction for the synthesis of 2,4-disubstituted dihydrotriazole-3-ones

Org Biomol Chem. 2022 May 11;20(18):3721-3725. doi: 10.1039/d2ob00352j.

Authors

Hui Liao¹, Zesheng Huang¹, Qiuhua Zhu¹

Affiliation

¹ Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, China. zhuqh@smu.edu.cn.

PMID: 35442256
DOI: 10.1039/d2ob00352j

Abstract

A series of 2,4-disubstituted 1,2,4-triazole-3-ones 4 were prepared via an iodine-DMSO-promoted three-component reaction of formaldehyde, amines and hydrazines in moderate yields.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amines
Dimethyl Sulfoxide
Hydrazines
Iodides
Iodine*
Molecular Structure

Substances

Amines
Hydrazines
Iodides
Iodine
Dimethyl Sulfoxide