Design and synthesis of a deep tissue penetrating near-infrared two-photon fluorescence probe for the specific detection of NQO1

Wenjing Wu; Xing Li; Lingyu Zhao; Shumu Li; Juanjuan Han; Yangyang Zhang; Zhenwen Zhao

doi:10.1039/d2cc01654k

Design and synthesis of a deep tissue penetrating near-infrared two-photon fluorescence probe for the specific detection of NQO1

Chem Commun (Camb). 2022 May 5;58(37):5634-5637. doi: 10.1039/d2cc01654k.

Authors

Wenjing Wu^{1

2}, Xing Li^{1

2}, Lingyu Zhao^{1

2}, Shumu Li¹, Juanjuan Han¹, Yangyang Zhang^{1

2}, Zhenwen Zhao^{1

2}

Affiliations

¹ Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. zhangyy@iccas.ac.cn.
² University of Chinese Academy of Sciences, Beijing 100049, China.

PMID: 35438109
DOI: 10.1039/d2cc01654k

Abstract

NAD(P)H:quinone oxidoreductase 1 (NQO1) is overexpressed in a broad range of human tumors but remains difficult to study. Herein, we report a novel two-photon fluorescent probe with NIR emission for NQO1 detection. The probe demonstrated superior analytical performance with a large Stokes shift and deep tissue penetration.

MeSH terms

Fluorescence
Fluorescent Dyes
Humans
NAD(P)H Dehydrogenase (Quinone)*
Neoplasms*
Photons

Substances

Fluorescent Dyes
NAD(P)H Dehydrogenase (Quinone)
NQO1 protein, human