Polymeric nanoparticles in the diagnosis and treatment of myocardial infarction: Challenges and future prospects

Mia Karam; Duaa Fahs; Batoul Maatouk; Brouna Safi; Ayad A Jaffa; Rami Mhanna

doi:10.1016/j.mtbio.2022.100249

Polymeric nanoparticles in the diagnosis and treatment of myocardial infarction: Challenges and future prospects

Mater Today Bio. 2022 Apr 4:14:100249. doi: 10.1016/j.mtbio.2022.100249. eCollection 2022 Mar.

Authors

Mia Karam^{1

2}, Duaa Fahs^{1

2}, Batoul Maatouk^{1

2}, Brouna Safi³, Ayad A Jaffa², Rami Mhanna¹

Affiliations

¹ Biomedical Engineering Program, Maroun Semaan Faculty of Engineering and Architecture, Lebanon.
² Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, P.O. Box 11-0236, Beirut, Lebanon.
³ Department of Chemical Engineering, Maroun Semaan Faculty of Engineering and Architecture, Lebanon.

Abstract

Myocardial infarction (MI) is the leading cause of morbidity and mortality worldwide. Despite extensive efforts to provide early diagnosis and adequate treatment regimens, detection of MI still faces major limitations and pathological MI complications continue to threaten the recovery of survivors. Polymeric nanoparticles (NPs) represent novel noninvasive drug delivery systems for the diagnosis and treatment of MI and subsequent prevention of fatal heart failure. In this review, we cover the recent advances in polymeric NP-based diagnostic and therapeutic approaches for MI and their application as multifunctional theranostic tools. We also discuss the in vivo behavior and toxicity profile of polymeric NPs, their application in noninvasive imaging, passive, and active drug delivery, and use in cardiac regenerative therapy. We conclude with the challenges faced with polymeric nanosystems and suggest future efforts needed for clinical translation.

Keywords: Diagnosis; Myocardial infarction; Polymeric nanoparticles; Table of contents; Theranostics; Treatment.

Publication types

Review