Association of Secretor Status and Recent Norovirus Infection With Gut Microbiome Diversity Metrics in a Veterans Affairs Population

Jordan A Johnson; Timothy D Read; Robert A Petit 3rd; Vincent C Marconi; Kathryn L Meagley; Maria C Rodriguez-Barradas; David O Beenhouwer; Sheldon T Brown; Mark Holodniy; Cynthia A Lucero-Obusan; Patricia Schirmer; Jessica M Ingersoll; Colleen S Kraft; Frederick H Neill; Robert L Atmar; Anita K Kambhampati; Jordan E Cates; Sara A Mirza; Aron J Hall; Cristina V Cardemil; Benjamin A Lopman

doi:10.1093/ofid/ofac125

Association of Secretor Status and Recent Norovirus Infection With Gut Microbiome Diversity Metrics in a Veterans Affairs Population

Open Forum Infect Dis. 2022 Mar 11;9(5):ofac125. doi: 10.1093/ofid/ofac125. eCollection 2022 May.

Authors

Jordan A Johnson¹, Timothy D Read¹, Robert A Petit 3rd¹, Vincent C Marconi¹, Kathryn L Meagley¹, Maria C Rodriguez-Barradas^{2

3}, David O Beenhouwer⁴, Sheldon T Brown⁵, Mark Holodniy^{6

7

8}, Cynthia A Lucero-Obusan^{6

7}, Patricia Schirmer^{6

7}, Jessica M Ingersoll⁹, Colleen S Kraft^{1

9}, Frederick H Neill¹⁰, Robert L Atmar^{7

10}, Anita K Kambhampati¹¹, Jordan E Cates¹¹, Sara A Mirza¹¹, Aron J Hall¹¹, Cristina V Cardemil¹¹, Benjamin A Lopman¹

Affiliations

¹ Department of Epidemiology, Emory University Rollins School of Public Health, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, and Atlanta Veterans Affairs Medical Center, Atlanta, Georgia, USA.
² Infectious Diseases Section, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA.
³ Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
⁴ Veterans Affairs Greater Los Angeles Health System, Los Angeles, California, USA.
⁵ James J. Peters Veterans Affairs Medical Center, Bronx, New York, USA.
⁶ Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
⁷ Office of Population Health, Public Health Surveillance and Research, Veterans Health Administration, Washington, DC, USA.
⁸ Division of Infectious Diseases & Geographic Medicine, Stanford University, Stanford, California, USA.
⁹ Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
¹⁰ Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
¹¹ Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Abstract

Norovirus infection causing acute gastroenteritis could lead to adverse effects on the gut microbiome. We assessed the association of microbiome diversity with norovirus infection and secretor status in patients from Veterans Affairs medical centers. Alpha diversity metrics were lower among patients with acute gastroenteritis but were similar for other comparisons.

Keywords: acute gastroenteritis; microbiome; norovirus; secretor status.

Grants and funding

P01 AI057788/AI/NIAID NIH HHS/United States