Coronary Microvascular Angina: A State-of-the-Art Review

Francesco Spione; Victor Arevalos; Rami Gabani; Manel Sabaté; Salvatore Brugaletta

doi:10.3389/fcvm.2022.800918

Coronary Microvascular Angina: A State-of-the-Art Review

Front Cardiovasc Med. 2022 Mar 30:9:800918. doi: 10.3389/fcvm.2022.800918. eCollection 2022.

Authors

Francesco Spione^{1

2}, Victor Arevalos², Rami Gabani², Manel Sabaté², Salvatore Brugaletta²

Affiliations

¹ Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
² Hospital Clínic, Cardiovascular Clinic Institute, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Abstract

Up to 60-70% of patients, undergoing invasive coronary angiography due to angina and demonstrable myocardial ischemia with provocative tests, do not have any obstructive coronary disease. Coronary microvascular angina due to a dysfunction of the coronary microcirculation is the underlying cause in almost 50% of these patients, associated with a bad prognosis and poor quality of life. In recent years, progress has been made in the diagnosis and management of this condition. The aim of this review is to provide an insight into current knowledge of this condition, from current diagnostic methods to the latest treatments.

Keywords: INOCA; coronary flow reserve; coronary microvascular dysfunction; microvascular angina; vasospastic angina.

Publication types

Review