The Differential Expression of CD47 may be Related to the Pathogenesis From Myelodysplastic Syndromes to Acute Myeloid Leukemia

Xiao Yan; Binbin Lai; Xuyan Zhou; Shujun Yang; Qunfang Ge; Miao Zhou; Cong Shi; Zhijuan Xu; Guifang Ouyang

doi:10.3389/fonc.2022.872999

The Differential Expression of CD47 may be Related to the Pathogenesis From Myelodysplastic Syndromes to Acute Myeloid Leukemia

Front Oncol. 2022 Mar 31:12:872999. doi: 10.3389/fonc.2022.872999. eCollection 2022.

Authors

Xiao Yan¹, Binbin Lai¹, Xuyan Zhou², Shujun Yang³, Qunfang Ge¹, Miao Zhou¹, Cong Shi⁴, Zhijuan Xu¹, Guifang Ouyang¹

Affiliations

¹ Haematology Department of Ningbo First Hospital, Ningbo Clinical Research Center for Hematologic Malignancies, Ningbo, China.
² Haematology Department, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, China.
³ Medical Research Center of Ningbo First Hospital, Ningbo, China.
⁴ Stem Cell Transplantation Laboratory of Ningbo First Hospital, Institute of Hematology of Ningbo First Hospital, Ningbo, China.

Abstract

Myelodysplastic syndrome (MDS) can lead to the development of peripheral blood cytopenia and abnormal cell morphology. MDS has the potential to evolve into AML and can lead to reduced survival. CD47, a member of the immunoglobulin family, is one molecule that is overexpressed in a variety of cancer cells and is associated with clinical features and poor prognosis in a variety of malignancies. In this study, we analyzed the expression and function of CD47 in MDS and AML, and further analyzed its role in other tumors. Our analysis revealed significantly low CD47 expression in MDS and significantly high expression in AML. Further analysis of the function or pathway of CD47 from different perspectives identified a relationship to the immune response, cell growth, and other related functions or pathways. The relationship between CD47 and other tumors was analyzed from four aspects: DNA methyltransferase, TMB, MSI, and tumor cell stemness. Changes in gene expression levels have a known association with aberrant DNA methylation, and this methylation is the main mechanism of tumor suppressor gene silencing and clonal variation during the evolution of MDS to AML. Taken together, our findings support the hypothesis that the differential expression of CD47 might be related to the transformation of MDS to AML.

Keywords: AML; DNA methylation; cd47; expression; mds.