Increased Risk of Temporomandibular Joint Disorder in Osteoporosis Patients: A Longitudinal Study

So Young Kim; Dae Myoung Yoo; Mi Jung Kwon; Ji Hee Kim; Joo-Hee Kim; Soo-Hwan Byun; Bumjung Park; Hyo-Jeong Lee; Hyo Geun Choi

doi:10.3389/fendo.2022.835923

Increased Risk of Temporomandibular Joint Disorder in Osteoporosis Patients: A Longitudinal Study

Front Endocrinol (Lausanne). 2022 Mar 31:13:835923. doi: 10.3389/fendo.2022.835923. eCollection 2022.

Authors

So Young Kim¹, Dae Myoung Yoo², Mi Jung Kwon³, Ji Hee Kim⁴, Joo-Hee Kim⁵, Soo-Hwan Byun^{6

7}, Bumjung Park⁸, Hyo-Jeong Lee⁸, Hyo Geun Choi^{2

8}

Affiliations

¹ Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
² Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, South Korea.
³ Department of Pathology, Hallym University College of Medicine, Anyang, South Korea.
⁴ Department of Neurosurgery, Hallym University College of Medicine, Anyang, South Korea.
⁵ Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Hallym University College of Medicine, Anyang, South Korea.
⁶ Department of Oral and Maxillofacial Surgery, Dentistry, Hallym University College of Medicine, Anyang, South Korea.
⁷ Research Center of Clinical Dentistry, Hallym University Clinical Dentistry Graduate School, Chuncheon, South Korea.
⁸ Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Anyang, South Korea.

Abstract

Background: The objective of this study was to investigate the risk of temporomandibular joint disorder (TMD) in patients with osteoporosis.

Methods: Data from the Korean National Health Insurance Service-Health Screening Cohort from 2002 to 2015 were collected. Participants ≥ 40 years old were enrolled, and the history of osteoporosis was evaluated. The 62,328 osteoporosis patients were matched for age, sex, income, and region of residence with 62,328 control participants. The occurrence of TMD was assessed in both the osteoporosis and control groups during the follow-up period. Stratified Cox proportional hazard analyses for TMD were conducted for the osteoporosis and control groups. The hazard ratios (HRs) of osteoporosis for TMD were further analyzed by age and sex subgroups.

Results: A total of 1.2% (725/61,320) of the osteoporosis patients and 0.6% (339/61,320) of the control participants had TMD (P<0.001). Osteoporosis was associated with an elevated HR of TMD (adjusted HR=1.96, 95% CI=1.72-2.23, P<0.001). Among the age and sex subgroups, the < 60-year-old mal\e group demonstrated an adjusted HR of osteoporosis for TMD as high as 4.47 (95% CI=1.17-17.12, P=0.029). Other age and sex subgroups also showed a higher HR for TMD associated with osteoporosis (adjusted HR=2.30, 95% CI=1.90-2.78, P<0.001 for the ≥ 60-year-old female group).

Conclusion: Osteoporosis was related to a higher risk of TMD in the adult population. A prominent association of osteoporosis with TMD was noted in middle-aged men and older women.

Keywords: cohort studies; epidemiology; osteoporosis; risk factors; temporomandibular joint disorders.

Publication types

Case Reports

MeSH terms

Adult
Aged
Cohort Studies
Female
Humans
Longitudinal Studies
Male
Middle Aged
Osteoporosis* / complications
Osteoporosis* / epidemiology
Risk Factors
Temporomandibular Joint Disorders* / complications
Temporomandibular Joint Disorders* / epidemiology