Peripheral Blood Circular RNAs as a Biomarker for Major Depressive Disorder and Prediction of Possible Pathways

Dandan Zhang; Yao Ji; Xiongjin Chen; RunSen Chen; Yaxue Wei; Qian Peng; Juda Lin; Jingwen Yin; Hezhan Li; Lili Cui; Zhixiong Lin; Yujie Cai

doi:10.3389/fnins.2022.844422

Peripheral Blood Circular RNAs as a Biomarker for Major Depressive Disorder and Prediction of Possible Pathways

Front Neurosci. 2022 Mar 31:16:844422. doi: 10.3389/fnins.2022.844422. eCollection 2022.

Authors

Dandan Zhang^{1

2}, Yao Ji¹, Xiongjin Chen¹, RunSen Chen³, Yaxue Wei², Qian Peng², Juda Lin², Jingwen Yin², Hezhan Li⁴, Lili Cui¹, Zhixiong Lin², Yujie Cai¹

Affiliations

¹ Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
² Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
³ Department of Rehabilitation Medicine Guangzhou Red Cross Hospital Affiliated to Jinan University, Guangzhou, China.
⁴ School of Humanities and Management, Guangdong Medical University, Dongguan, China.

Abstract

Circular RNAs (circRNAs) are highly expressed in the central nervous system and have been reported to be associated with neuropsychiatric diseases, but their potential role in major depressive disorder (MDD) remains unclear. Here, we demonstrated that there was a disorder of circRNAs in the blood of MDD patients. It has been preliminarily proved that hsa_circ_0002473, hsa_circ_0079651, hsa_circ_0137187, hsa_circ_0006010, and hsa_circ_0113010 were highly expressed in MDD patients and can be used as diagnostic markers for MDD. Bioinformatics analysis revealed that hsa_circ_0079651, hsa_circ_0137187, hsa_circ_0006010, and hsa_circ_0113010 may affect the neuroplasticity of MDD through the ceRNA mechanism.

Keywords: bioinformatics analysis; biomarker; circular RNA; major depressive disorder; neuroplasticity.