Tuberculosis and autoimmunity: Common features

A Starshinova; А Malkova; I Kudryavtsev; D Kudlay; Yu Zinchenko; P Yablonskiy

doi:10.1016/j.tube.2022.102202

Tuberculosis and autoimmunity: Common features

Tuberculosis (Edinb). 2022 May:134:102202. doi: 10.1016/j.tube.2022.102202. Epub 2022 Apr 4.

Authors

A Starshinova¹, А Malkova², I Kudryavtsev³, D Kudlay⁴, Yu Zinchenko⁵, P Yablonskiy⁶

Affiliations

¹ Head of the Research Department, Almazov National Medical Research Centre, 2, Akkuratov str, Saint-Petersburg, 197341, Russia. Electronic address: starshinova_aa@almazovcentre.ru.
² Laboratory of the Mosaic of Autoimmunity, St-Petersburg State University, 7-9, University Embankment, Saint-Petersburg, 199034, Russia. Electronic address: anya.malkova.95@mail.ru.
³ Laboratory of the Mosaic of Autoimmunity, St. Petersburg State University, Institution of Experimental Medicine, department of Immunology, acad. Pavlov str., 12, 197376, St. Petersburg, Russia. Electronic address: igorek1981@yandex.ru.
⁴ Department of Pharmacology, Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University, Russian Federation, Laboratory of Personalized Medicine and Molecular Immunology, 24, Kashirskoye highway, Moscow, 115552, Russia; NRC Institute of Immunology FMBA of Russia, 24, Kashirskoye highway, Moscow, 115552, Russia. Electronic address: D624254@gmail.com.
⁵ St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation, Ligovskii prospect, 2-4, Saint-Petersburg, 191036, Russia. Electronic address: ulia-zinchenko@yandex.ru.
⁶ Laboratory of the Mosaic of Autoimmunity, St-Petersburg State University, 7-9, University Embankment, Saint-Petersburg, 199034, Russia; St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation, Ligovskii prospect, 2-4, Saint-Petersburg, 191036, Russia. Electronic address: piotr_yablonskii@mail.ru.

PMID: 35430551
DOI: 10.1016/j.tube.2022.102202

Abstract

Despite the proven infectious nature of tuberculosis, new data have recently appeared on the autoimmune component in the course of tuberculosis infection. This chapter discusses the currently known signs of autoimmune inflammation in tuberculosis infection, including both clinical and immunological manifestations. Taking into account the available data on the possible triggering effect of M. tuberculosis on the development of the autoimmune process, the correction of these autoimmune complications may be a key moment in prescribing therapy and in predicting the low efficacy of the treatment of the disease.

Keywords: ASIA; Autoantibodies; Autoimmunity; HLA; Molecular mimicry; Tuberculosis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Autoantibodies
Autoimmune Diseases* / complications
Autoimmune Diseases* / drug therapy
Autoimmunity
Humans
Inflammation
Mycobacterium tuberculosis*
Tuberculosis* / diagnosis
Tuberculosis* / drug therapy
Tuberculosis* / epidemiology

Substances

Autoantibodies