A preliminary biodistribution study of [99mTc]sodium pertechnetate prepared from an electron linear accelerator and activated carbon-based 99mTc generator

Jaewoong Jang; Yoshitaka Kumakura; Katsuyoshi Tatenuma; Atsuko Nakanishi Ozeki; Youichiro Wada; Nobuyoshi Akimitsu; Akira Tsuguchi; Hidetoshi Kikunaga; Shogo Higaki; Mitsuru Uesaka

doi:10.1016/j.nucmedbio.2022.03.002

A preliminary biodistribution study of [^99mTc]sodium pertechnetate prepared from an electron linear accelerator and activated carbon-based ^99mTc generator

Nucl Med Biol. 2022 Jul-Aug:110-111:1-9. doi: 10.1016/j.nucmedbio.2022.03.002. Epub 2022 Mar 17.

Authors

Affiliations

¹ Department of Bioengineering, School of Engineering, University of Tokyo, Bunkyo, Tokyo 113-8656, Japan. Electronic address: jangj@korea.ac.kr.
² Department of Diagnostic Radiology and Nuclear Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama 350-8550, Japan; Isotope Science Center, University of Tokyo, Bunkyo, Tokyo 113-0032, Japan.
³ Kaken Inc., Mito, Ibaraki 310-0903, Japan.
⁴ Isotope Science Center, University of Tokyo, Bunkyo, Tokyo 113-0032, Japan.
⁵ Research Center for Electron Photon Science, Tohoku University, Sendai, Miyagi 982-0826, Japan.
⁶ Department of Bioengineering, School of Engineering, University of Tokyo, Bunkyo, Tokyo 113-8656, Japan; Nuclear Professional School, School of Engineering, University of Tokyo, Naka, Ibaraki 319-1188, Japan.

PMID: 35429894
DOI: 10.1016/j.nucmedbio.2022.03.002

Abstract

Introduction: Production of ⁹⁹Mo/^99mTc using an electron linear accelerator (linac) and activated carbon (AC)-based ^99mTc generator (linac-AC) is an alternative approach to the conventional fission production of ⁹⁹Mo/^99mTc. As a preliminary investigation of the clinical applicability of a linac-AC-derived ^99mTc radiopharmaceutical, the biodistribution of linac-AC-derived [^99mTc]sodium pertechnetate ([^99mTc]NaTcO₄) was measured and compared against fission-derived [^99mTc]NaTcO₄ at one time point.

Methods: ⁹⁹Mo was produced by irradiating nonenriched MoO₃ targets with bremsstrahlung photons generated from 55.5-MeV linac electron beams. ^99mTc was then separated and purified from the ⁹⁹Mo using an AC-based ^99mTc generator. Subsequently, biodistribution of the linac-AC-derived [^99mTc]NaTcO₄ in healthy female Slc:ICR mice (n = 6) was measured by dissection and compared with that of fission-derived [^99mTc]NaTcO₄ (n = 4) at 30 min after injection.

Results: The two types of [^99mTc]NaTcO₄ exhibited similar biodistribution in all the organs and tissues examined: the uptakes of [^99mTc]NaTcO₄ prepared from the linac-AC method and those prepared from the fission method were 138.9 ± 69.9%ID/g and 160.6 ± 49.2%ID/g in the thyroids, respectively, 33.4 ± 5.5%ID/g and 29.4 ± 9.1%ID/g in the salivary glands, respectively, and less than 10%ID/g in blood and all the other organs. No adverse effects were observed in the mice administered with either [^99mTc]NaTcO₄.

Conclusion: The clinical applicability of linac-AC-derived [^99mTc]NaTcO₄ was suggested by its similar biodistribution with fission-derived [^99mTc]NaTcO₄ at one time point. Further biodistribution studies at multiple time points are encouraged to demonstrate the bioequivalence between linac-AC- and fission-derived [^99mTc]NaTcO₄.

Keywords: (99)Mo; (99m)Tc; Activated carbon; Biodistribution; Electron linear accelerator; Pertechnetate.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Charcoal*
Electrons
Female
Mice
Mice, Inbred ICR
Particle Accelerators
Sodium
Sodium Pertechnetate Tc 99m*
Tissue Distribution

Substances

Charcoal
Sodium
Sodium Pertechnetate Tc 99m