Hyperpolarised NMR to aid molecular profiling of electronic cigarette aerosols

Ben J Tickner; Sanna Komulainen; Sanna Palosaari; Janne Heikkinen; Petri Lehenkari; Vladimir V Zhivonitko; Ville-Veikko Telkki

doi:10.1039/d1ra07376a

Hyperpolarised NMR to aid molecular profiling of electronic cigarette aerosols

RSC Adv. 2022 Jan 10;12(3):1479-1485. doi: 10.1039/d1ra07376a. eCollection 2022 Jan 5.

Authors

Ben J Tickner¹, Sanna Komulainen¹, Sanna Palosaari^{2

3}, Janne Heikkinen², Petri Lehenkari^{2

3

4}, Vladimir V Zhivonitko¹, Ville-Veikko Telkki¹

Affiliations

¹ NMR Research Unit, Faculty of Science, University of Oulu 90014 Finland vladimir.zhivonitko@oulu.fi ville-veikko.telkki@oulu.fi.
² Cancer and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu 90014 Finland.
³ Medical Research Center Oulu, Faculty of Medicine, University of Oulu and Oulu University Hospital 90014 Finland.
⁴ Division of Orthopedic Surgery, Oulu University Hospital 90220 Finland.

Abstract

Signal amplification by reversible exchange (SABRE) hyperpolarisation is used to enhance the NMR signals of nicotine and acrolein in methanol-d₄ solutions of electronic cigarette aerosols. Consequently, detection of 74 μM nicotine is possible in just a single scan ¹H NMR spectrum. The first example of an aldehyde hyperpolarised using SABRE is demonstrated and we work towards novel real-world applications of SABRE-hyperpolarised NMR for chemical analysis.