An anthracenecarboximide-guanidine fluorescent probe for selective detection of glyoxals under weak acidic conditions

Junwei Chen; Yuna Lin; Wanjin Xing; Xingchen Zhang; Huan Xu; Wei Wang; Kaiyan Lou

doi:10.1039/d2ra00741j

An anthracenecarboximide-guanidine fluorescent probe for selective detection of glyoxals under weak acidic conditions

RSC Adv. 2022 Mar 25;12(15):9473-9477. doi: 10.1039/d2ra00741j. eCollection 2022 Mar 21.

Authors

Junwei Chen¹, Yuna Lin¹, Wanjin Xing¹, Xingchen Zhang¹, Huan Xu¹, Wei Wang², Kaiyan Lou¹

Affiliations

¹ State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science & Technology 130 Meilong Road Shanghai 200237 China xuhuan@ecust.edu.cn kylou@ecust.edu.cn.
² A Department of Pharmacology and Toxicology and BIO5 Institute, University of Arizona Tucson AZ 85721-0207 USA wwang@pharmacy.arizona.edu.

Abstract

An anthracenecarboximide-guanidine based turn-on fluorescent probe ANC-DCP-1 for selective detection of glyoxals (methylglyoxal and glyoxal, GOS) over formaldehyde under weak acidic conditions around pH 6.0 was reported. The probe showed great potential in studying relative GOS levels in weak acidic biological fluids such as in urine for diabetic diagnosis and prognosis, and also found application in the food industry such as for fast unique manuka factor (UMF) scale determination of Manuka honey.