Knecorticosanones C-H from the fruits of Knema globularia (Lam.) warb

Chindawadee Chuenban; Aonnicha Sombatsri; Thurdpong Sribuhom; Chanakan Pornchoo; Auemduan Prawan; Sarawut Tontapha; Vittaya Amornkitbamrung; Chavi Yenjai

doi:10.1039/d0ra10498a

Knecorticosanones C-H from the fruits of Knema globularia (Lam.) warb

RSC Adv. 2021 Jan 20;11(7):4097-4103. doi: 10.1039/d0ra10498a. eCollection 2021 Jan 19.

Authors

Chindawadee Chuenban¹, Aonnicha Sombatsri¹, Thurdpong Sribuhom¹, Chanakan Pornchoo², Auemduan Prawan², Sarawut Tontapha³, Vittaya Amornkitbamrung³, Chavi Yenjai¹

Affiliations

¹ Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University Khon Kaen 40002 Thailand chayen@kku.ac.th +66-4320-2222-41 ext. 12243.
² Department of Pharmacology, Faculty of Medicine, Khon Kaen University Khon Kaen 40002 Thailand.
³ Integrated Nanotechnology Research Centre, Department of Physics, Faculty of Science, Khon Kaen University Khon Kaen 40002 Thailand.

Abstract

Six undescribed polyketides, 1-6, were discovered from the fruits of Knema globularia (Lam.) warb. Two known polyketides and three known lignans were also isolated. Cytotoxicities against HepG2 and KKU-M156 cells of all polyketides were evaluated. Compound 1 displayed the most cytotoxic activity against HepG2 and KKU-M156 cell lines with IC₅₀ values of 1.57 ± 0.37 and 1.78 ± 0.14 μg mL^-1, respectively. The structure of all isolates was identified using spectroscopic methods including NMR, IR, MS and ECD.