1-Acryloyl-2-cyanoindole: A Skeleton for Visible-Light-Induced Cascade Annulation

An-Xiang Huang; Hu-Lin Zhu; Fan-Lin Zeng; Xiao-Lan Chen; Xian-Qiang Huang; Ling-Bo Qu; Bing Yu

doi:10.1021/acs.orglett.2c00927

1-Acryloyl-2-cyanoindole: A Skeleton for Visible-Light-Induced Cascade Annulation

Org Lett. 2022 Apr 29;24(16):3014-3018. doi: 10.1021/acs.orglett.2c00927. Epub 2022 Apr 14.

Authors

An-Xiang Huang¹, Hu-Lin Zhu¹, Fan-Lin Zeng¹, Xiao-Lan Chen¹, Xian-Qiang Huang², Ling-Bo Qu¹, Bing Yu¹

Affiliations

¹ Green Catalysis Center, College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
² School of Chemistry & Chemical Engineering, Liaocheng University, Liaocheng, Shandong 252059, China.

PMID: 35420829
DOI: 10.1021/acs.orglett.2c00927

Abstract

1-Acryloyl-2-cyanoindoles were found to be novel and efficient skeletons in visible-light-induced persulfate-promoted cascade cyclization reactions. With this transition-metal-free photocatalytic procedure, various sulfonated/thiocyanated pyrrolo[1,2-a]indolediones were synthesized from 1-acryloyl-2-cyanoindoles with sulfonyl hydrazides/NH₄SCN at room temperature under mild reaction conditions.