Rising Interest in the Development of Metal Complexes in Cancer Immunotherapy

Chem Asian J. 2022 Jul 1;17(13):e202200270. doi: 10.1002/asia.202200270. Epub 2022 May 24.

Abstract

Metal complexes have shown great potential in cancer immunotherapy. This review briefly introduces the basic concepts and strategies of cancer immunotherapy and summarizes the recent discoveries on the immune effects of traditional platinum-based anticancer compounds. In addition, we also outline the latest research progresses on metal complexes for cancer immunotherapy focusing on platinum, ruthenium, iridium, rhenium and copper complexes. Finally, the research perspectives and unsolved problems on the applications of metallo-anticancer agents in cancer immunotherapy are purposed.

Keywords: cancer; immunotherapy; metal complexes.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents* / pharmacology
  • Antineoplastic Agents* / therapeutic use
  • Coordination Complexes* / pharmacology
  • Coordination Complexes* / therapeutic use
  • Humans
  • Immunotherapy
  • Iridium
  • Neoplasms* / drug therapy
  • Ruthenium* / pharmacology
  • Ruthenium* / therapeutic use

Substances

  • Antineoplastic Agents
  • Coordination Complexes
  • Iridium
  • Ruthenium