Greasy GLUT1 maintains glioblastoma malignancy

Caiyun Liu; Xinjian Li

doi:10.1080/23723556.2021.2009423

Greasy GLUT1 maintains glioblastoma malignancy

Mol Cell Oncol. 2021 Dec 8;8(6):2009423. doi: 10.1080/23723556.2021.2009423. eCollection 2021.

Authors

Caiyun Liu^{1

2}, Xinjian Li^{1

2}

Affiliations

¹ CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
² College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.

Abstract

How cancer cells absorb enough glucose to support their rapid growth is poorly understood. We have recently demonstrated that palmitoyl transferase DHHC9 palmitoylates glucose transporter GLUT1 at Cys207 to maintain GLUT1 plasma membrane localization. DHHC9-mediated GLUT1 palmitoylation supports glycolysis, proliferation, colony formation, and tumorigenicity of glioblastoma cells.

Keywords: DHHC9; GLUT1; glioblastoma; palmitoylation.

Grants and funding

This work was supported by the Key Program of the Chinese Academy of Sciences (Grant no. KJZD-SW-L05 to X.L.); the National Natural Science Foundation of China (Grant no. 82073060 to X.L.); and the National Key R&D Program of China (Grant no. 2020YFC2002700 to X.L.).