Antibiotic-Eluting Envelopes for the Prevention of Cardiac Implantable Electronic Device Infections: Rationale, Efficacy, and Cost-Effectiveness

Vassil Traykov; Carina Blomström-Lundqvist

doi:10.3389/fcvm.2022.855233

Antibiotic-Eluting Envelopes for the Prevention of Cardiac Implantable Electronic Device Infections: Rationale, Efficacy, and Cost-Effectiveness

Front Cardiovasc Med. 2022 Mar 28:9:855233. doi: 10.3389/fcvm.2022.855233. eCollection 2022.

Authors

Vassil Traykov¹, Carina Blomström-Lundqvist^{2

3}

Affiliations

¹ Department of Invasive Electrophysiology, Acibadem City Clinic Tokuda University Hospital, Sofia, Bulgaria.
² Department of Medical Science, Uppsala University, Uppsala, Sweden.
³ Department of Cardiology, Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, Sweden.

Abstract

Infections related to cardiac implantable electronic devices (CIED) are associated with significant morbidity and mortality. Despite optimal use of antimicrobials and other preventive strategies, the incidence of CIED infections is increasing over time leading to considerable costs to the healthcare systems. Recently, antibiotic-eluting envelopes (AEEs) have been introduced as a promising technology to prevent CIED infections. This review will address the current evidence on stratification of CIED infection risk, present the rationale behind AEE, and summarize the currently available evidence for CIED infection prevention as well as demonstrate the cost-effectiveness of this novel technology.

Keywords: antibiotic eluting envelope; cardiac implantable electronic device; cardiac resynchronization therapy; cost-effectiveness; implantable cardioverter defibrillator; infection; pacemaker.

Publication types

Review