Correlation Analysis of Plasma Myeloperoxidase Level With Global Registry of Acute Coronary Events Score and Prognosis in Patients With Acute Non-ST-Segment Elevation Myocardial Infarction

Nan Zhang; Jing-Xian Wang; Xiao-Yuan Wu; Yan Cui; Zhong-He Zou; Yin Liu; Jing Gao

doi:10.3389/fmed.2022.828174

Correlation Analysis of Plasma Myeloperoxidase Level With Global Registry of Acute Coronary Events Score and Prognosis in Patients With Acute Non-ST-Segment Elevation Myocardial Infarction

Front Med (Lausanne). 2022 Mar 28:9:828174. doi: 10.3389/fmed.2022.828174. eCollection 2022.

Authors

Nan Zhang^{1

2}, Jing-Xian Wang¹, Xiao-Yuan Wu¹, Yan Cui¹, Zhong-He Zou¹, Yin Liu^{1

2}, Jing Gao^{1

3}

Affiliations

¹ Thoracic Clinical College, Tianjin Medical University, Tianjin, China.
² Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.
³ Cardiovascular Institute, Tianjin Chest Hospital, Tianjin, China.

Abstract

Background: Myeloperoxidase (MPO) and global registry of acute coronary events (GRACE) risk scores were independently used to predict adverse outcomes in patients with acute coronary syndrome (ACS). However, the relationship between MPO level and GRACE score, and whether the combination of MPO and GRACE can better predict major adverse cardiovascular events (MACEs) in patients with acute non-ST-segment elevation myocardial infarction (NSTEMI), have not been previously investigated.

Methods: A prospective cohort of 271 consecutive patients with NSTEMI were enrolled in this study. Plasma MPO levels were measured by ELISA. Baseline demographic and clinical information was collected, and GRACE scores were calculated at admission. The correlation between MPO and MACEs was evaluated with the GRACE score during a 1-year follow-up.

Results: The results showed that plasma MPO level was correlated with inflammatory indices (including high-sensitivity C-reactive protein (hs-CRP), leukocyte count, neutrophil count, and fibrinogen), N-terminal pro-B type natriuretic peptide (NT-proBNP), and hypersensitive troponin T (hsTNT) levels (All p-values < 0.05), and there was a statistically significant correlation between plasma MPO level and GRACE score (r = 0.22, p < 0.001). The Kaplan-Meier curves showed that patients with higher MPO levels had lower event-free survival (Log-rank P < 0.001). The multivariate Cox model showed MPO was an independent risk factor for 1-year MACEs in patients with NSTEMI (HR: 3.85, 95% CI: 1.4-10.6, p = 0.009). Subgroup analysis showed that MPO was a strong prognostic biomarker, and its prognostic value was more significant in patients with age >65 years and N-terminal pro-B type natriuretic peptide (NT-proBNP) level >1,000 pg/ml. For high-risk patients with GRACE scores, a higher level of MPO has a higher prognostic value.

Conclusion: Elevated plasma MPO levels are associated with high inflammatory status and GRACE scores in patients with NSTEMI. For high-risk patients with GRACE scores, higher MPO levels were more predictive of future MACEs.

Keywords: GRACE score; MACE; NSTEMI; myeloperoxidase; prognosis.