Oxidative RNA Damage in the Pathogenesis and Treatment of Type 2 Diabetes

Xiatian Chen; Hua Yu; Zhe Li; Wei Ye; Ziqian Liu; Jinning Gao; Yin Wang; Xin Li; Lei Zhang; Natalia Alenina; Michael Bader; Hongyan Ding; Peifeng Li; Lynn Htet Htet Aung

doi:10.3389/fphys.2022.725919

Oxidative RNA Damage in the Pathogenesis and Treatment of Type 2 Diabetes

Front Physiol. 2022 Mar 28:13:725919. doi: 10.3389/fphys.2022.725919. eCollection 2022.

Authors

Xiatian Chen^{1

2}, Hua Yu³, Zhe Li^{1

2}, Wei Ye⁴, Ziqian Liu^{1

2}, Jinning Gao¹, Yin Wang¹, Xin Li¹, Lei Zhang¹, Natalia Alenina⁵, Michael Bader⁵, Hongyan Ding⁶, Peifeng Li¹, Lynn Htet Htet Aung¹

Affiliations

¹ Center for Molecular Genetics, Institute of Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
² School of Basic Medicine, Qingdao University, Qingdao, China.
³ The Affiliated Cardiovascular Hospital of Qingdao University, Qingdao, China.
⁴ Jiangsu Provincial Engineering Research Center for Biomedical Materials and Advanced Medical Device, Huaiyin Institute of Technology, Huaian, China.
⁵ Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany.
⁶ School of Bioengineering, Suqian University, Suqian, China.

Abstract

Excessive production of free radicals can induce cellular damage, which is associated with many diseases. RNA is more susceptible to oxidative damage than DNA due to its single-stranded structure, and lack of protective proteins. Yet, oxidative damage to RNAs received little attention. Accumulating evidence reveals that oxidized RNAs may be dysfunctional and play fundamental role in the occurrence and development of type 2 diabetes (T2D) and its complications. Oxidized guanine nucleoside, 8-oxo-7, 8-dihydroguanine (8-oxoGuo) is a biomarker of RNA oxidation that could be associated with prognosis in patients with T2D. Nowadays, some clinical trials used antioxidants for the treatment of T2D, though the pharmacological effects remained unclear. In this review, we overview the cellular handling mechanisms and the consequences of the oxidative RNA damage for the better understanding of pathogenesis of T2D and may provide new insights to better therapeutic strategy.

Keywords: 8-oxoGuo; RNA oxidation; oxidative damage; therapeutic strategy; type 2 diabetes.

Publication types

Review