Does chromatin function as a metabolite reservoir?

Vinícius D Nirello; Dieggo Rodrigues de Paula; Nathália V P Araújo; Patrick D Varga-Weisz

doi:10.1016/j.tibs.2022.03.016

Does chromatin function as a metabolite reservoir?

Trends Biochem Sci. 2022 Sep;47(9):732-735. doi: 10.1016/j.tibs.2022.03.016. Epub 2022 Apr 11.

Authors

Vinícius D Nirello¹, Dieggo Rodrigues de Paula¹, Nathália V P Araújo¹, Patrick D Varga-Weisz²

Affiliations

¹ International Laboratory for Microbiome Host Epigenetics, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.
² São Paulo Chair of Excellence, International Laboratory for Microbiome Host Epigenetics, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil; School of Life Sciences, University of Essex, Colchester, UK. Electronic address: Patrick.varga-weisz@essex.ac.uk.

PMID: 35418348
DOI: 10.1016/j.tibs.2022.03.016

Abstract

Alternative histone acylations integrate gene expression with cellular metabolic states. Recent measurements of cellular acyl-coenzyme A (acyl-CoA) pools highlight the potential that histone post-translational modifications (PTMs) contribute directly to the regulation of metabolite pools. A metabolite-centric view throws new light onto roles and evolution of histone PTMs.

Keywords: acyl-CoA; acylations; chromatin; histone modifications; metabolism; quiescence.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acyl Coenzyme A / metabolism
Acylation
Chromatin*
Histones* / metabolism
Protein Processing, Post-Translational

Substances

Acyl Coenzyme A
Chromatin
Histones

Abstract

Publication types

MeSH terms

Substances

Grants and funding