Emerging Argonaute-based nucleic acid biosensors

Yuqing Qin; Yingjun Li; Yonggang Hu

doi:10.1016/j.tibtech.2022.03.006

Emerging Argonaute-based nucleic acid biosensors

Trends Biotechnol. 2022 Aug;40(8):910-914. doi: 10.1016/j.tibtech.2022.03.006. Epub 2022 Apr 10.

Authors

Yuqing Qin¹, Yingjun Li², Yonggang Hu³

Affiliations

¹ State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, P.R. China; Hubei Hongshan Laboratory, Wuhan 430070, P.R. China.
² State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, P.R. China; Shenzhen Institute of Nutrition and Health, Huazhong Agricultural University, Shenzhen, Guangdong 518000, P.R. China; Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, Guangdong 518120, P.R. China. Electronic address: yingjun@mail.hzau.edu.cn.
³ State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, P.R. China; Hubei Hongshan Laboratory, Wuhan 430070, P.R. China. Electronic address: yongganghu@mail.hzau.edu.cn.

PMID: 35418313
DOI: 10.1016/j.tibtech.2022.03.006

Abstract

Recent advances in Argonaute (Ago)-mediated biotechnology have provided new insights into the development of programmable and highly sensitive nucleic acid detection platforms. This study provides an overview of recent research on Ago-based nucleic acid detection. The potential applications of these emerging nucleic acid biosensors and the challenges associated with their use have been discussed.

Keywords: Argonaute; SARS-CoV-2 detection; early diagnostics for cancer; in vivo imaging; multiplexed biosensing; nucleic acid biosensor; short nucleic acid analysis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biosensing Techniques*
Nucleic Acids*

Substances

Nucleic Acids