Microbes-myeloid-tumor: a colonic triad against T cells

Amélie Lopès; Romina S Goldszmid

doi:10.1016/j.immuni.2022.03.011

Microbes-myeloid-tumor: a colonic triad against T cells

Immunity. 2022 Apr 12;55(4):582-585. doi: 10.1016/j.immuni.2022.03.011.

Authors

Amélie Lopès¹, Romina S Goldszmid²

Affiliations

¹ Inflammatory Cell Dynamics Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
² Inflammatory Cell Dynamics Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Electronic address: rgoldszmid@mail.nih.gov.

PMID: 35417671
DOI: 10.1016/j.immuni.2022.03.011

Abstract

Immune checkpoint blockade has dramatically improved cancer therapy but remains ineffective for most colorectal tumors. In this issue of Immunity, Peuker et al. describe a microbiota-myeloid-tumor cell crosstalk that inhibits CD8⁺ T cells and promotes colorectal cancer progression.

Published by Elsevier Inc.

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MeSH terms

CD8-Positive T-Lymphocytes*
Cell Line, Tumor
Colorectal Neoplasms*
Humans
Lymphocyte Count
Myeloid Cells / pathology
Tumor Microenvironment