Positron emission tomography molecular imaging-based cancer phenotyping

Chentao Jin; Xiaoyun Luo; Xiaoyi Li; Rui Zhou; Yan Zhong; Zhoujiao Xu; Chunyi Cui; Xiaoqing Xing; Hong Zhang; Mei Tian

doi:10.1002/cncr.34228

Positron emission tomography molecular imaging-based cancer phenotyping

Cancer. 2022 Jul 15;128(14):2704-2716. doi: 10.1002/cncr.34228. Epub 2022 Apr 13.

Authors

Chentao Jin^{1

2

3}, Xiaoyun Luo^{1

2

3}, Xiaoyi Li^{1

2

3}, Rui Zhou^{1

2

3}, Yan Zhong^{1

2

3}, Zhoujiao Xu^{1

2

3}, Chunyi Cui^{1

2

3}, Xiaoqing Xing^{1

2

3}, Hong Zhang^{1

2

3

4

5}, Mei Tian^{1

2

3}

Affiliations

¹ Department of Nuclear Medicine and Positron Emission Tomography Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
² Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China.
³ Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China.
⁴ College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.
⁵ Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, China.

Abstract

During the past several decades, numerous studies have provided insights into biological characteristics of cancer cells and identified various hallmarks of cancer acquired in the tumorigenic processes. However, it is still challenging to image these distinctive traits of cancer to facilitate the management of patients in clinical settings. The rapidly evolving field of positron emission tomography (PET) imaging has provided opportunities to investigate cancer's biological characteristics in vivo. This article reviews the current status of PET imaging on characterizing hallmarks of cancer and discusses the future directions of PET imaging strategies facilitating in vivo cancer phenotyping.

Keywords: biomarker; cancer; cancer hallmarks; molecular imaging; positron emission tomography (PET); translational medicine.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Molecular Imaging
Neoplasms* / diagnostic imaging
Positron-Emission Tomography* / methods