The role of ubiquitination and deubiquitination in tumor invasion and metastasis

Int J Biol Sci. 2022 Mar 6;18(6):2292-2303. doi: 10.7150/ijbs.69411. eCollection 2022.

Abstract

Ubiquitination is vital for multiple cellular processes via dynamic modulation of proteins related to cell growth, proliferation, and survival. Of the ubiquitination system components, E3 ubiquitin ligases and deubiquitinases have the most prominent roles in modulating tumor metastasis. This review will briefly summarize the observations and underlying mechanisms of multiple E3 ubiquitin ligases and deubiquitinases to regulate tumor metastasis. Further, we will discuss the relationship and importance between ubiquitination components and tumor progression.

Keywords: E3 ubiquitin ligase; deubiquitinase; metastasis; ubiquitination.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Deubiquitinating Enzymes / metabolism
  • Humans
  • Neoplasms* / metabolism
  • Ubiquitin / metabolism
  • Ubiquitin-Protein Ligases* / genetics
  • Ubiquitin-Protein Ligases* / metabolism
  • Ubiquitination

Substances

  • Ubiquitin
  • Ubiquitin-Protein Ligases
  • Deubiquitinating Enzymes