History and classification of Aigai virus (formerly Crimean-Congo haemorrhagic fever virus genotype VI)

Anna Papa; Marco Marklewitz; Sofia Paraskevopoulou; Aura R Garrison; Sergey V Alkhovsky; Tatjana Avšič-Županc; Dennis A Bente; Éric Bergeron; Felicity Burt; Nicholas Di Paola; Koray Ergünay; Roger Hewson; Ali Mirazimi; Amadou Alpha Sall; Jessica R Spengler; Thomas S Postler; Gustavo Palacios; Jens H Kuhn

doi:10.1099/jgv.0.001734

History and classification of Aigai virus (formerly Crimean-Congo haemorrhagic fever virus genotype VI)

J Gen Virol. 2022 Apr;103(4):001734. doi: 10.1099/jgv.0.001734.

Authors

Anna Papa^{1

2}, Marco Marklewitz³, Sofia Paraskevopoulou³, Aura R Garrison^{2

4

5}, Sergey V Alkhovsky^{2

6}, Tatjana Avšič-Županc^{2

5

7}, Dennis A Bente^{2

8}, Éric Bergeron^{2

5

9}, Felicity Burt^{10

2

5}, Nicholas Di Paola^{2

4

5}, Koray Ergünay^{11

2

5}, Roger Hewson^{12

2

5}, Ali Mirazimi^{13

2

5}, Amadou Alpha Sall^{14

2}, Jessica R Spengler^{2

9}, Thomas S Postler¹⁵, Gustavo Palacios^{2

4

5}, Jens H Kuhn^{16

2

5}

Affiliations

¹ National Reference Centre for Arboviruses and Haemorrhagic Fever Viruses (Εθνικό Κέντρο Αναφοράς Αρμποϊών και Αιμορραγικών πυρετών, 1st Laboratory of Microbiology (Α' Εργαστήριο Μικροβιολογίας), School of Medicine (Τμήμα Ιατρικής), Aristotle University of Thessaloniki (Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης), Thessaloniki, Greece.
² The members of the 2017-2020 International Committee on Taxonomy of Viruses (ICTV) Nairoviridae Study Group.
³ Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
⁴ United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
⁵ The members of the 2020-2023 International Committee on Taxonomy of Viruses (ICTV) Nairoviridae Study Groups.
⁶ D. I. Ivanovsky Institute of Virology of the N. F. Gamaleya National Center on Epidemiology and Microbiology of Ministry of Health of Russian Federation (Институт вирусологии им. Д. И. Ивановского, входящий в состав ФГБУ «НИЦЭМ им. Н. Ф. Гамалеи» Минздрава России), Moscow, Russia.
⁷ University of Ljubljana (Univerza v Ljubljani), Faculty of Medicine (Medicinska fakulteta), Slovenia.
⁸ University of Texas Medical Branch, Galveston, Texas, USA.
⁹ Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
¹⁰ Division of Virology, National Health Laboratory Service and Division of Virology, University of the Free State, Bloemfontein, South Africa.
¹¹ Virology Unit (Viroloji Birimi), Department of Medical Microbiology (Tıbbi Mikrobiyoloji Anabilim Dalı), Faulty of Medicine (Tıp Fakültesi), Hacettepe University (Hacettepe Üniversitesi), Ankara, Turkey.
¹² Public Health England, Porton Down, Wiltshire, Salisbury, UK.
¹³ Folkhalsomyndigheten, Stockholm, Sweden.
¹⁴ Institut Pasteur de Dakar, Dakar, Senegal.
¹⁵ Department of Microbiology & Immunology, Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
¹⁶ Integrated Research Facility at Fort Detrick. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA.

Abstract

Crimean-Congo haemorrhagic fever virus (CCHFV) is the medically most important member of the rapidly expanding bunyaviral family Nairoviridae. Traditionally, CCHFV isolates have been assigned to six distinct genotypes. Here, the International Committee on Taxonomy of Viruses (ICTV) Nairoviridae Study Group outlines the reasons for the recent decision to re-classify genogroup VI (aka Europe-2 or AP-92-like) as a distinct virus, Aigai virus (AIGV).

Keywords: AIGV; Aigai virus; Crimean–Congo hemorrhagic fever; Nairoviridae; orthonairovirus.

History and classification of Aigai virus (formerly Crimean-Congo haemorrhagic fever virus genotype VI)

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