This article provides an overview (non-comprehensive) of the recent developments regarding pyridine-containing 12-membered tetraazamacrocycles with pyclen or Py2N2 backbones and their metal complexes from 2017 to the present. Firstly, the syntheses of newly described ligands and complexes with relevance to medicine are described. The second part deals with the reactivity of complexes bearing these ligands and their uses in catalysis. Special emphasis on the role of the pyridine-containing ligand is highlighted throughout the text.