YB-1 as an Oncoprotein: Functions, Regulation, Post-Translational Modifications, and Targeted Therapy

Qiyan Yin; Min Zheng; Qianmei Luo; Dewei Jiang; Huifeng Zhang; Ceshi Chen

doi:10.3390/cells11071217

YB-1 as an Oncoprotein: Functions, Regulation, Post-Translational Modifications, and Targeted Therapy

Cells. 2022 Apr 4;11(7):1217. doi: 10.3390/cells11071217.

Authors

Qiyan Yin¹, Min Zheng^{2

3}, Qianmei Luo², Dewei Jiang^{2

3}, Huifeng Zhang⁴, Ceshi Chen^{2

5

6}

Affiliations

¹ Medical Faculty, Kunming University of Science and Technology, Kunming 650504, China.
² Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming 650201, China.
³ Kunming College of Life Sciences, The University of the Chinese Academy of Sciences, Kunming 650201, China.
⁴ Department of Clinical Pharmacy, The First People's Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, China.
⁵ Academy of Biomedical Engineering, Kunming Medical University, Kunming 650500, China.
⁶ The Third Affiliated Hospital, Kunming Medical University, Kunming 650118, China.

Abstract

Y box binding protein 1 (YB-1) is a protein with a highly conserved cold shock domain (CSD) that also belongs to the family of DNA- and RNA-binding proteins. YB-1 is present in both the nucleus and cytoplasm and plays versatile roles in gene transcription, RNA splicing, DNA damage repair, cell cycle progression, and immunity. Cumulative evidence suggests that YB-1 promotes the progression of multiple tumor types and serves as a potential tumor biomarker and therapeutic target. This review comprehensively summarizes the emerging functions, mechanisms, and regulation of YB-1 in cancers, and further discusses targeted strategies.

Keywords: RNA binding protein; YB-1; cancer; therapeutic target; transcription factor.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell Nucleus / metabolism
DNA-Binding Proteins / metabolism
Oncogene Proteins* / metabolism
Protein Processing, Post-Translational
Y-Box-Binding Protein 1* / genetics
Y-Box-Binding Protein 1* / metabolism

Substances

DNA-Binding Proteins
Oncogene Proteins
Y-Box-Binding Protein 1