Abietane diterpenes from the twigs and leaves of Cephalotaxus oliveri Mast. with antitumor activity

Chunyu Jiang; Mengyue Yang; Chunxue Zhao; Fangshen Liu; Hangao Yang; Zhanlin Li; Tong Han; Bin Lin; Dahong Li; Huiming Hua

doi:10.1016/j.phytochem.2022.113187

Abietane diterpenes from the twigs and leaves of Cephalotaxus oliveri Mast. with antitumor activity

Phytochemistry. 2022 Jul:199:113187. doi: 10.1016/j.phytochem.2022.113187. Epub 2022 Apr 8.

Authors

Chunyu Jiang¹, Mengyue Yang¹, Chunxue Zhao¹, Fangshen Liu¹, Hangao Yang¹, Zhanlin Li¹, Tong Han², Bin Lin¹, Dahong Li³, Huiming Hua⁴

Affiliations

¹ Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, And School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
² Department of Pharmaceutical Engineering, College of Life Science & Technology, Heilongjiang Bayi Agricultural University, 5 Xinfeng Road, Daqing, 163319, PR China.
³ Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, And School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China. Electronic address: lidahong0203@163.com.
⁴ Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, And School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China. Electronic address: huimhua@163.com.

PMID: 35405149
DOI: 10.1016/j.phytochem.2022.113187

Abstract

Twenty one abietane diterpenes were isolated from Cephalotaxus oliveri Mast. The structures of 7 undescribed diterpenoids, named cephaloliverins A-G, were elucidated via spectroscopic data interpretation and electronic circular dichroism (ECD) analysis. The isolated diterpenoids were evaluated for their cytotoxicity against three kinds of human tumor cell lines (MCF-7, HepG2, and A549). Metaglyptin A was the most active with IC₅₀ values of 16.34, 15.63 and 21.33 μM and was further investigated for colony formation and apoptosis in HepG2 cells.

Keywords: Abietane diterpenes; Antitumor activity; Cephalotaxaceae; Cephalotaxus oliveri Mast..

MeSH terms

Abietanes / chemistry
Abietanes / pharmacology
Antineoplastic Agents, Phytogenic* / chemistry
Antineoplastic Agents, Phytogenic* / pharmacology
Cell Line, Tumor
Cephalotaxus* / chemistry
Diterpenes* / chemistry
Molecular Structure
Plant Leaves / chemistry

Substances

Abietanes
Antineoplastic Agents, Phytogenic
Diterpenes