Electrochemical Dearomatization of Indoles: Access to Diversified Fluorine-Containing Spirocyclic Indolines

Kangdong Mo; Xiaocong Zhou; Ju Wu; Yufen Zhao

doi:10.1021/acs.orglett.2c00530

Electrochemical Dearomatization of Indoles: Access to Diversified Fluorine-Containing Spirocyclic Indolines

Org Lett. 2022 Apr 22;24(15):2788-2792. doi: 10.1021/acs.orglett.2c00530. Epub 2022 Apr 11.

Authors

Kangdong Mo¹, Xiaocong Zhou¹, Ju Wu^{1

2}, Yufen Zhao^{1

2}

Affiliations

¹ Institute of Drug Discovery Technology, Ningbo University, 315211 Ningbo, Zhejiang, China.
² Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, 315211 Ningbo, Zhejiang, China.

PMID: 35404622
DOI: 10.1021/acs.orglett.2c00530

Abstract

A robust and green electrochemical dearomatization of indoles was developed by merging a fluorine-containing group to an indole nucleus under oxidant-free conditions, delivering a diverse array of tri- and difluoromethylated 3,3-spiroindolines with good functional group tolerance.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Fluorine*
Indoles*

Substances

Indoles
Fluorine