A Retrospective Study of the Relationship Between the Triglyceride Glucose Index and Myocardial Revascularization for New-Onset Acute Coronary Syndromes

Jiatian Li; Yajuan Lin; Han Li; Rui Fan; Li Lin; Xinying Wang; Yinong Jiang; Yun-Long Xia; Bo Zhang; Xiaolei Yang

doi:10.3389/fcvm.2022.862252

A Retrospective Study of the Relationship Between the Triglyceride Glucose Index and Myocardial Revascularization for New-Onset Acute Coronary Syndromes

Front Cardiovasc Med. 2022 Mar 24:9:862252. doi: 10.3389/fcvm.2022.862252. eCollection 2022.

Authors

Jiatian Li¹, Yajuan Lin¹, Han Li¹, Rui Fan¹, Li Lin¹, Xinying Wang¹, Yinong Jiang², Yun-Long Xia², Bo Zhang², Xiaolei Yang¹

Affiliations

¹ Institute of Cardiovascular Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
² Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

Abstract

Background: This study explored the relationship between the TyG index/serum uric acid (SUA) panel and myocardial revascularization (MRT) for new-onset acute coronary syndromes (ACS).

Methods: Between January 2011 and July 2020, 13,271 new-onset ACS patients were enrolled. The logistic regression models and the odds ratios (ORs) were used to quantify the risk of TyG index/SUA and MRT. Then, interaction analyses of TyG index and SUA on MRT were applied.

Results: Elevated TyG index was positively associated higher risks of MRT. However, SUA levels were negatively associated with MRT. Compared with those in the lowest quartile, the risk of MRT increased gradually among patients in Q1 of the SUA category (OR = 1.03, 1.11, and 1.28 for Q2, Q3, and Q4 of TyG index, respectively), Q2 of the SUA category (OR = 1.41, 1.68, and 2.18 for Q2, Q3, and Q4 of TyG index, respectively), Q3 of the SUA category (OR = 1.05, 1.45, and 1.45 for Q2, Q3, and Q4 of TyG index, respectively), and Q4 of the SUA category (OR = 1.20, 1.29, and 1.46 for Q2, Q3, and Q4 of TyG index, respectively). This pattern was observed in both male and female, as well as patients without type 2 diabetes mellitus.

Conclusion: Patients with a higher TyG index have a higher proportion of MRT in new-onset ACS. This result also applies to patients with different levels of SUA during new-onset ACS.

Keywords: TyG index; acute coronary syndromes; coronary artery disease; myocardial revascularization; serum uric acid.