A rare case of ovarian gonadoblastoma flourishing into malignant mixed germ cell tumour with review of literature

Tarang Patel; Bhamini Jakhetiya; Ashish Jakhetiya; Virendrakumar Meena

doi:10.1007/s13691-021-00531-w

A rare case of ovarian gonadoblastoma flourishing into malignant mixed germ cell tumour with review of literature

Int Cancer Conf J. 2022 Jan 6;11(2):114-118. doi: 10.1007/s13691-021-00531-w. eCollection 2022 Apr.

Authors

Tarang Patel¹, Bhamini Jakhetiya², Ashish Jakhetiya³, Virendrakumar Meena⁴

Affiliations

¹ Department of Pathology, All India Institute of Medical Sciences, Rajkot, Gujarat India.
² Department of Gynecology and Obstetrics, Geetanjali Medical College & Hospital, Udaipur, India.
³ Department of Surgical Oncology, Geetanjali Medical College & Hospital, Udaipur, India.
⁴ Department of Radiodiagnosis, Geetanjali Medical College & Hospital, Udaipur, India.

Abstract

Gonadoblastoma is an extremely rare neoplasm of the ovary showing admixture of germ cells and sex cord cells. It may be associated with gonadal dysgenesis. Gonadoblastoma cells may give rise to individual germ cell tumours or mixed germ cell tumours with variable tumour components. Very few cases of ovarian gonadoblastoma admixed with malignant germ cell tumours have been recorded worldwide. Because of the rareness of the tumour, a component of gonadoblastoma might be overlooked on microscopic examination. Here we report a rare case of ovarian gonadoblastoma giving rise to an admixture of immature teratoma and dysgerminoma. We discuss microscopic features, immunohistochemistry findings and review of literature.

Keywords: Dysgerminoma; Immature teratoma; Inhibin; Ovarian gonadoblastoma; PLAP; SALL4.

Publication types

Case Reports