CRNDE: A valuable long noncoding RNA for diagnosis and therapy of solid and hematological malignancies

Xuefei Ma; Wen Jin; Chaoxian Zhao; Xuefeng Wang; Kankan Wang

doi:10.1016/j.omtn.2022.03.006

CRNDE: A valuable long noncoding RNA for diagnosis and therapy of solid and hematological malignancies

Mol Ther Nucleic Acids. 2022 Mar 9:28:190-201. doi: 10.1016/j.omtn.2022.03.006. eCollection 2022 Jun 14.

Authors

Xuefei Ma^{1

2}, Wen Jin^{2

3}, Chaoxian Zhao^{2

3}, Xuefeng Wang¹, Kankan Wang^{2

3}

Affiliations

¹ Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
² Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
³ CNRS-LIA Hematology and Cancer, Sino-French Research Center for Life Sciences and Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Abstract

Colorectal neoplasia differentially expressed (CRNDE) is an oncogenic long noncoding RNA (lncRNA). Increased CRNDE expression was initially discovered in colorectal cancer and then in a variety of solid tumors and hematological malignancies. CRNDE participates in multiple biological processes, such as cell proliferation, differentiation, migration, and apoptosis. CRNDE has been shown to modulate target gene expression through multiple mechanisms, including transcriptional regulation, post-transcriptional regulation, and competition for microRNA (miRNA) binding. In this review, we summarize the evidence that supports CRNDE in the diagnosis and prognosis predicting of cancers. The functional roles and molecular mechanisms of CRNDE are further described for major types of solid tumors and hematological malignancies. The therapeutic potential of CRNDE as a target for research and development is also discussed.

Keywords: CRNDE; MT: Non-coding RNAs; clinical value; hematological malignancy; long noncoding RNA; molecular mechanism; solid tumor.

Publication types

Review