Pembrolizumab-induced Myasthenia Gravis Relapse after Immunosuppressive Therapy

Intern Med. 2022 Nov 1;61(21):3281-3285. doi: 10.2169/internalmedicine.8554-21. Epub 2022 Apr 9.

Abstract

Myasthenia gravis (MG) is an immune-related adverse event (irAE), and as an irAE, MG (irAE-MG) generally has a monophasic course, with only a few case reports of irAE-MG flare-ups during the course of the disease. We herein report a case of pembrolizumab-induced MG with relapsing symptoms. irAE-MG is a rare disease that has not yet been fully characterized, and our case shows that MG symptoms may relapse. Therefore, regular follow-up is necessary, even after the symptoms improve with immunosuppressive therapy.

Keywords: an immune-related adverse event; immunosuppressive; myasthenia gravis; pembrolizumab; recurrence; relapse.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Monoclonal, Humanized / adverse effects
  • Humans
  • Immunosuppression Therapy
  • Myasthenia Gravis* / chemically induced
  • Myasthenia Gravis* / diagnosis
  • Myasthenia Gravis* / drug therapy
  • Neoplasm Recurrence, Local* / drug therapy

Substances

  • pembrolizumab
  • Antibodies, Monoclonal, Humanized