Emerging Mechanisms and Targeted Therapy of Pyroptosis in Central Nervous System Trauma

Biao Yang; Weijie Zhong; Ying Gu; Yi Li

doi:10.3389/fcell.2022.832114

Emerging Mechanisms and Targeted Therapy of Pyroptosis in Central Nervous System Trauma

Front Cell Dev Biol. 2022 Mar 25:10:832114. doi: 10.3389/fcell.2022.832114. eCollection 2022.

Authors

Biao Yang^{1

2}, Weijie Zhong¹, Ying Gu³, Yi Li¹

Affiliations

¹ Department of Neurosurgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
³ Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.

Abstract

Cell death can occur in different modes, ferroptosis, pyroptosis, apoptosis, and necroptosis. Recent studies have shown that pyroptosis can be effectively regulated and that like necroptosis, pyroptosis has been regarded as a type of programmed cell death. The mechanism of its occurrence can be divided into canonical inflammasome-induced pyroptosis and noncanonical inflammasome-induced pyroptosis. In the past research, pyroptosis has been shown to be closely related to various diseases, such as tumors, neurodegenerative diseases, and central nervous system trauma, and studies have pointed out that in central nervous system trauma, pyroptosis is activated. Furthermore, these studies have shown that the inhibition of pyroptosis can play a role in protecting nerve function. In this review, we summarized the mechanisms of pyroptosis, introduce treatment strategies for targeted pyroptosis in central nervous system trauma, and proposed some issues of targeted pyroptosis in the treatment of central nervous system injury.

Keywords: pyroptosis; spinal cord injury; target; therapy; traumatic brain injury.

Publication types

Review