This study aimed to evaluate the effect of functional magnetic resonance imaging (fMRI) under the fuzzy C-means (FCM) clustering algorithm on plan-do-check-action (PDCA) home nursing for patients with diabetic nephropathy (DN). As the characteristics of fMRI image data were combined, the FCM algorithm was improved and applied into the clustering processing of fMRI activation regions of patients. 64 patients with DN were chosen as the research objects and were divided into the research group with PDCA home nursing and the control group with routine home nursing. The patients were randomly divided into the research group (n = 32) and the control group (n = 32). The curative effect, nursing satisfaction, and quality of life of patients after nursing were compared. The results showed that the coverage of fMRI activation points was significantly higher as being detected by the FCM algorithm, and the running time was shortened by 33.6 min. After nursing, the total effective rates in the research group and the control group were 87.5% vs. 34.4% in 3 months, 93.8% vs. 68.8% in 6 months, and 96.9% vs. 75.0% in 12 months, respectively; those in the research group were significantly higher than those in the control group (P < 0.05). The nursing satisfaction score (91.3 ± 4.5 vs. 80.9 ± 5.2) and nursing service quality score (89.7 ± 6.6 vs. 80.3 ± 7.1) in the research group were also significantly higher than those in the control group (P < 0.05). Meanwhile, the scores of each item after nursing in the research group were significantly higher than those in the control group (P < 0.05). The improved FCM algorithm detected the activation regions in the fMRI images more effectively, which could provide help for diagnosis and reduce error and misdiagnosis. At the same time, the PDCA home nursing also offered great help to the recovery of patients with DN, which was more superior for the curative effect of hospitalization, the promotion of recovery, and the improvement of patients' quality of life.
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