Generation of a human induced pluripotent stem cell line KUMi006 from a patient with multiple myeloma

Ji-Hyeon Hong; Ji-Hea Kim; Ka-Won Kang; Byung-Hyun Lee; Young Park; Byung-Soo Kim

doi:10.1016/j.scr.2022.102767

Generation of a human induced pluripotent stem cell line KUMi006 from a patient with multiple myeloma

Stem Cell Res. 2022 May:61:102767. doi: 10.1016/j.scr.2022.102767. Epub 2022 Mar 28.

Authors

Ji-Hyeon Hong¹, Ji-Hea Kim¹, Ka-Won Kang², Byung-Hyun Lee², Young Park², Byung-Soo Kim³

Affiliations

¹ Institute of Stem Cell Research, Korea University College of Medicine, Seoul, South Korea; Department of Biomedical and Science, Graduate School of Medicine, Korea University, Seoul, South Korea.
² Department of Internal Medicine, Korea University Medical School Hospital, Seoul, South Korea.
³ Institute of Stem Cell Research, Korea University College of Medicine, Seoul, South Korea; Department of Biomedical and Science, Graduate School of Medicine, Korea University, Seoul, South Korea; Department of Internal Medicine, Korea University Medical School Hospital, Seoul, South Korea. Electronic address: kbs0309@korea.ac.kr.

PMID: 35397398
DOI: 10.1016/j.scr.2022.102767

Abstract

In this study, we report the generation of a novel human induced pluripotent stem cell (hiPSC) line from bone marrow mononuclear cells of a patient with multiple myeloma, using an integrative Sendai virus vector. This pluripotent cell line has been shown to differentiate into three germ layers. Therefore, these induced pluripotent stem cells (iPSCs) will enable not only advances in cell therapy products but also the study of mechanisms.

MeSH terms

Cell Line
Germ Layers
Humans
Induced Pluripotent Stem Cells* / metabolism
Multiple Myeloma* / metabolism
Sendai virus / genetics