Objective: To investigate the difference of therapeutic effects on children with thalassemia at different age after hematopoietic stem cell transplantation.
Methods: The clinical data of children with thalassemia treated in our hospital were retrospectively analyzed. The children were divided into 2-5 years old group and 6-12 years old group. The success rate of implantation, transplant-related mortality, GVHD incidence, and other transplant-related complications, as well as thalassemia-free survival (TFS) were compared between the two groups.
Results: The incidence of GVHD, hemorrhagic cystitis and severe oral mucositis after transplantation in the 2-5 years old group were significantly lower than those in the 6-12 years old group, while there was no statistically significant difference in the TFS between the two groups.
Conclusion: Children in the low age (2-5 years old) group show fewer complications and higher quality of life after transplantation, therefore, stem cell transplantation at 2-5 years old is more conducive to rehabilitation of the children with thalassemia.
题目: 不同年龄段地中海贫血患儿接受异基因造血干细胞移植后疗效的比较.
目的: 探讨不同年龄段地中海贫血患儿接受造血干细胞移植后疗效的差异.
方法: 回顾性分析我科收治的地中海贫血患儿临床资料，以5岁为界，分为2-5岁组和6-12岁组，比较两组患儿植入成功率、移植相关死亡率、GVHD发生率和其他移植相关并发症差异，以及无地中海贫血生存率差异.
结果: 2-5岁组移植后GVHD发生率、出血性膀胱炎和重度口腔黏膜炎发生率均显著低于6-12岁组，两组无地中海贫血生存率比较差异无统计学意义.
结论: 低年龄组（2-5岁）患儿移植后并发症少，生存质量高，选择2-5岁之间进行干细胞移植更利于患儿的康复.
Keywords: age; allogeneic hematopoietic stem cell transplantation; complication; efficacy; thalassemia.